Very few participants dropped out of the studies due to these reactions. The most common side effects were injection site reaction such as pain, redness and swelling. Injectable PrEP was tolerated well by adults in the studies. After one half-life, the concentration of a drug in the body amounts to half the starting dose of any drug to be eliminated from the body. The amount of time it takes for a concentration in blood to be reduced by 50%. These results do not mean injectable PrEP is a better option for everyone but it may be more effective for people who do not want to rely on taking pills every day. PrEP tablets are an effective prevention method when taken as prescribed. This difference may be explained by very few people missing their PrEP injections but some missing their PrEP tablets during the studies. The studies reported fewer HIV infections in the groups on injectable PrEP compared to the groups taking tablets. Studies found the use of cabotegravir as injectable PrEP – which requires an injection every two months – at least as effective as the PrEP tablets. Other studies are currently looking at the safety, tolerability and effectiveness for adolescent males and females. The HPTN 084 study enrolled 3223 cisgender women aged 18-45 and reported long acting cabotegravir to be safe and effective in adult women. The HPTN 083 study, with 4566 participants, found long-acting cabotegravir safe and effective for men who have sex with men and trans women. This makes long-acting prevention possible. Injectable cabotegravir has a long half-life, meaning it can stay in the body for much longer than the tablets. When on PrEP tablets, you need to take your tablets every 24 hours to have enough levels of PrEP in your blood. Injections every two months are needed to keep high enough levels of cabotegravir in the blood to prevent HIV infection. Sperm: A cell made in the male testicles that can fertilize a female egg.The latest news and research on injectable & long-acting PrEP Infections include chlamydia, gonorrhea, human papillomavirus (HPV), herpes, syphilis, and human immunodeficiency virus (HIV, the cause of acquired immunodeficiency syndrome ). Sexually Transmitted Infection (STI): An infection that is spread by sexual contact. Semen: The fluid made by male sex glands that contains sperm. Along with other preventive measures, such as using condoms, PrEP may reduce the risk of getting HIV. Pre-Exposure Prophylaxis (PrEP): Daily medication taken to help prevent infection with human immunodeficiency virus (HIV). Ovulation: The time when an ovary releases an egg. Obstetrician–Gynecologist (Ob-Gyn): A doctor with special training and education in women's health. In Vitro Fertilization (IVF): A procedure in which an egg is removed from a woman's ovary, fertilized in a laboratory with the man's sperm, and then transferred to the woman's uterus to achieve a pregnancy. Intrauterine Insemination (IUI): A procedure in which a man's sperm is placed into a woman's uterus. Immune System: The body's natural defense system against viruses and bacteria that cause disease. If left untreated, HIV can cause acquired immunodeficiency syndrome (AIDS). Human Immunodeficiency Virus (HIV): A virus that attacks certain cells of the body's immune system. Acquired Immunodeficiency Syndrome (AIDS): A group of signs and symptoms, usually of severe infections, occurring in a person who has human immunodeficiency virus (HIV).īirth Defects: Physical problems that are present at birth.įetus: The stage of human development beyond 8 completed weeks after fertilization.

Prep medication